New skin gel fights breast cancer without blood clot risk

A gel form of tamoxifen applied to the breasts of women with noninvasive breast cancer reduced the growth of cancer cells to the same degree as the drug taken in oral form but with fewer side effects that deter some women from taking it, according to new Northwestern Medicine® research.

Tamoxifen is an oral drug that is used forbreast cancerprevention and as therapy for non-invasive breast cancer and invasive cancer.

因为药物通过皮肤吸收directly into breast tissue, blood levels of the drug were much lower, thus, potentially minimizing dangerous side effects—blood clots and uterine cancer.

Thegelwas tested on women diagnosed with the non-invasive cancer ductal carcinoma in situ (DCIS) in which abnormal cells multiply and form a growth in a milk duct. Because of potential side effects, many women with DCIS are reluctant to take oral tamoxifen after being treated with breast-saving surgery and radiation even though the drug effectively prevents DCIS recurrence and reduces risk of future new breast cancer.

The paper was published July 15 in the journalClinical Cancer Research.

"Delivering the drug though a gel, if proven effective in larger trials, could potentially replace oral tamoxifen for breastcancer preventionand DCIS and encourage many more women to take it," said lead author Seema Khan, M.D., a Northwestern Medicine® surgical oncologist. "For breast cancer prevention and DCIS therapy, effective drug concentrations are required in the breast. For these women, high circulating drug levels only cause collateral damage."

Khan is a professor of surgery and the Bluhm Family Professor of Cancer Research at Northwestern University Feinberg School of Medicine. She also is a surgeon at Northwestern Memorial Hospital and co-leader of the breast cancer program at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University

"The gel minimized exposure to the rest of the body and concentrated the drug in the breast where it is needed," Khan said. "There was very little drug in the bloodstream which should avoid potential blood clots as well as an elevated risk for uterine cancer."

Women who have completed surgery and radiation are given oral tamoxifen for five years to reduce the risk of the DCIS recurring at the same place and of new breast cancer appearing elsewhere in the same breast or the other breast. Tamoxifen is an anti-estrogen therapy for a type of breast cancer that requires estrogen to grow.

汗和他的同事们进行了二期临床trial to compare the effects of the gel, 4-OHT, with oral tamoxifen. They found after six to 10 weeks of gel application that the reduction in a marker for cancer cell growth, Ki-67, in breast tissue was similar to that of oral tamoxifen. The scientists also found equal amounts of 4-OHT present in thebreast tissueof patients who used the gel or took the oraldrug, but the blood levels of 4-OHT were more than five times lower in those who used the gel.

The reduction in the levels of 4-OHT in the blood also was correlated with a reduction in proteins that cause blood clots.

The study involved 26 women, ages 45 to 86, who had been diagnosed with DCIS that was sensitive to estrogen (estrogen-receptor-positive DCIS). Half the women received the gel, which they applied daily, and half theoral drug, which they took daily.

The gel application may also be more effective for some women. Oral tamoxifen doesn't help all women who take it because it needs to be activated in the liver by specific enzymes and about a third of women lack these enzymes, Khan said. Thesewomenmay not receive full benefits from the pill.