双向ABGC驱动的LPP和MPP诱发MGC响应的调节。(a)育种策略和TAM-归纳时间表。NES-Archt-GFP鼠标DG中ABGC的共聚焦图像。GCL,颗粒细胞层;GFP,绿色荧光蛋白;WPRE,WOODCHUCK肝炎病毒后术治疗元素。(b)实验方案:将双极刺激电极定位在LPP或MPP中。全电池电流钳位录制在GCS上进行(亮截面)和(亮型)致光学沉默于ABGC的致光学沉默,其中532纳米绿色激光通过40×目的突出。(c和e)(左)来自代表性ABGC尖刺的五个痕迹,以应对40赫兹火车刺激。刺激伪影在每次试验中显示20个脉冲(0.1毫秒)。 Blue and red traces indicate spike activity during Light-OFF and Light-ON conditions, respectively. (Right) Average abGC spike probability for each pulse in the train. (Inset) Average abGC spike probability per train. Error bars indicate SEM. (D and F) (Left) Average evoked synaptic potentials in a representative mGC. Shaded blue (Light-OFF) and red (Light-ON) areas indicate AUC. AUC = area above baseline (depolarization) minus area below baseline (hyperpolarization). (Right) Plots comparing Light-OFF versus Light-ON AUCs for each mGC. Scale bars: 20 mV, 50 ms [(C) and (E)]; 0.5 mV, 50 ms [(D) and (F)]. Credit:科学(2019)。DOI: 10.1126 / science.aat8789
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