Researchers discover new stem cells that can generate new bone

A population of stem cells with the ability to generate new bone has been newly discovered by a group of researchers at the UConn School of Dental Medicine.

In the journalStem Cells, lead investigator Dr. Ivo Kalajzic, professor of reconstructive sciences, postdoctoral fellows Dr. Sierra Root and Dr. Natalie Wee, and collaborators at Harvard, Maine Medical Research Center, and the University of Auckland present a new population of cells that reside along the vascular channels that stretch across the bone and connect the inner and outer parts of the bone.

"This is a new discovery of perivascular cells residing within the bone itself that can generate new bone forming cells," said Kalajzic. "These cells likely regulate bone formation or participate in bone mass maintenance and repair."

Stem cells for bone have long been thought to be present withinbone marrowand the outer surface of bone, serving as reserve cells that constantly generate new bone or participate in bone repair.Recent studieshave described the existence of a network of vascular channels that helped distributeblood cells的骨髓,但没有研究证明the existence of cells within these channels that have the ability to form new bones.

In this study, Kalajzic and his team are the first to report the existence of these progenitor cells within cortical bone that can generate new bone-forming cells—osteoblasts—that can be used to help remodel a bone.

To reach this conclusion, the researchers observed thestem cellswithin an ex vivo bone transplantation model. These cells migrated out of the transplant, and began to reconstruct the bone marrow cavity and form new bone.

While this study shows there is a population of cells that can help aid bone formation, more research needs to be done to determine thecells' potential to regulateboneformation and resorption.