Covid-19大多数癌症患者对没有癌症的人有类似的免疫反应

大多数患有新型冠状病毒感染的癌症的人以与剩余的人口相当的速率产生抗体 - 但它们的能力取决于他们的癌症类型和他们收到的治疗，根据新的研究Montefiore Health System和Albert爱因斯坦医学院的研究人员。今天在线发布的调查结果自然癌症，可能导致患癌症患者的癌症患者，他们面临着从Covid-19死亡的高度风险，并表明癌症患者应对Covid-19疫苗进行良好响应。

“我们关注的是我们的研究癌症患者who develop COVID-19 may not benefit from the same degree of antibody protection as people without cancer, given that many are immuno-compromised," said Astha Thakkar, M.B.B.S., a Montefiore hematologic oncology fellow and first author of the paper. "Our findings provide assurance that most people with cancer are able to mount an antibody response to the coronavirus that is similar to the general population. People with a history of cancer are likely as protected from reinfection as those without a history of disease and are likely to respond well to vaccines, according to our study."

这回顾性研究涉及261名癌症患者，77％的人被诊断患有固体恶性肿瘤，23％与血液学（血液）恶性肿瘤。它们的血清转换总体率（生产）抗体响应感染）是92％。然而，当比较固体和血汗恶性肿瘤的患者时，血液癌的患者的血清转化率仅为81.7％ - 实体肿瘤患者的94.5％血清转换率。

“众所周知，常规给予患有血液癌患者的治疗患者 - 抗CD20抗体治疗，干细胞移植和类固醇 - 可抑制免疫系统，这可以解释这些患者中发育的较低率及其风险增加severe COVID-19 disease," said senior author Balazs Halmos, M.D., M.S., director of the Multidisciplinary Thoracic Oncology Program at Montefiore, professor of medicine at Einstein, and a member of the Albert Einstein Cancer Center (AECC).

"We need to pay special attention to patients with blood cancers and think through proactive strategies to ensure this patient population is appropriately cared for," said Sanjay Goel, M.B.B.S., a medical oncologist at Montefiore, professor of medicine at Einstein, a member of AECC, and a coauthor on the paper. "This study also raises the need for additional research on COVID-19 vaccines and current treatments for people with blood cancer."

在去年发布的论文中癌症发现哈尔莫斯博士和同事发现Covid-19患者血液与具有实体肿瘤的患者相比，癌症的死亡率显着更高。比活性癌症治疗的年龄和共同生命性更密切相关。

该研究参与者在2020年3月1日至9月15日至9月15日至9月15日至9月15日至9月15日至9月15日至9月15日，通过PCR试验测试了Covid-19的阳性，以通过抗体检测或两者检测冠状病毒或先前的Covid-19暴露。患者平均年龄为64岁，在男人和女性之间几乎均匀地分裂。56％的患者（147/261）有症状冠状病毒感染，而44％（114/261）有无症状感染。

超过40％的患者是非洲裔美国人;30％是西班牙裔人，近15％是高加索人，3％是亚洲人，6％属于其他民族。

本文标题为“患者恶性疾病和抗病患者的SARS-COV2-IgG血清转化模式”标题。癌症治疗。”

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