研究发现高达24％的食道切除术患者可以在可操作地开发VTE

今天在今天的AATS 101年级会议上提出了一项新的研究，发现患有静脉血栓栓塞（VTE）的癌症患者的患者的百分比高于先前报道，多达24％患有深静脉血栓形成（DVT）或肺栓塞（PE）。VTE患者的六个月死亡率为17.6％，而那些没有2.1％。

静脉血栓栓塞（VTE）是一种常见的潜在可预防的术后并发症，导致显着的发病率和死亡率。食管切除术病人由于疾病负担、手术规模和高围手术期发病率，是静脉血栓栓塞的高危人群之一。该研究旨在量化食管切除术后静脉血栓栓塞的真实发生率风险因素以及VTE对患者结果的影响。

在2017年11月和2020年11月期间八个第六份中心在八个第六份中心接受食管切除术的患者入学前瞻性队列研究。所有患者均接受基于指南的静脉血栓栓塞预防治疗直到出院出院前行双下肢静脉-多普勒超声检查(DUS)，术后30天、90天及60天行CT-PE检查。每隔一段时间测量d -二聚体水平，术后随访6个月。

According to Yaron Shargall, M.D., FRCSC, professor and chair of the division of Thoracic Surgery at McMaster University and study leader, despite the fact that all patients were treated with VTE prophylaxis according to best practices, a high proportion would have been discharged home with VTE under standard protocols, or would have developed VTE after discharge. "When we followed this cohort of patients for six months, we saw VTE events develop mostly within one month of surgery, but also as long as six months. Even more importantly, we found that those who developed VTE had a seven-fold increase in mortality at six months, the reasons for which are yet to be determined" says Shargall. "We are yet to define if active screening for VTE in all esophagectomy patients is really justified, and if a longer duration of VTE prophylaxis, beyond the住院他补充道。

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