疫苗对SARS-COV-2充满自然免疫力
![Plasma ELISAs and neutralizing activity. a-b, Plasma IgG antibody binding to SARS-CoV-2 RBD (a) and N protein (b), and plasma neutralizing activity (c–e) 12 months after infection (N=63). a and b, ELISA curves from non-vaccinated (black lines) individuals, as well as individuals who received one or two doses of a COVID-19 mRNA vaccine (blue lines), respectively (left panels). Area under the curve (AUC) over time in non-vaccinated and vaccinated individuals, as indicated (middle panels). Two individuals who received their first dose of vaccine 24-48 hours before sample collection are depicted in purple. Lines connect longitudinal samples. Numbers in red indicate geometric mean AUC at the indicated timepoint. Right most panel shows combined values as a dot plot for all individuals. c, ranked average NT50 at 1.3 months (light grey) and 6.2 months (dark grey), as well as at 12 months for non-vaccinated (orange) individuals, and individuals who received one or two doses (blue circles) of a COVID-19 mRNA vaccine, respectively. Two individuals who received their first dose of vaccine 24-48 hours before sample collection are depicted in purple. d, e, NT50 over time in non-vaccinated (d) and vaccinated individuals (e). Lines connect longitudinal samples from the same individual. Two individuals who received their first dose of vaccine 24-48 hours before sample collection are depicted in purple. Red numbers indicate the geometric mean NT50 at the indicated timepoint. Statistical significance in a, b, d and e was determined using Friedman Multiple Comparisons test. f, Plasma neutralizing activity against SARS-CoV-2 variants of concern. All experiments were performed at least in duplicate. 疫苗对SARS-COV-2充满自然免疫力](https://scx1.b-cdn.net/csz/news/800a/2021/vaccines-charge-up-nat.jpg)
根据新的研究,在最初感染后,已经对Covid的人享有冠心病的强烈免疫力。在分析患者血液中存在的抗体时,洛克菲勒的科学家能够跟踪这些可变分子的演变。他们发现疫苗接种促进这些人在感染时自然发育的免疫力,即使从新出现的变体也可能受到保护。
这项研究中的63人在去年春季进行了Covid。来自他们的后续的数据表明,随着时间的推移,免疫系统的记忆B细胞产生的抗体在中和SARS-COV-2时变得越来越好,表明这些人正在为病毒制定一种改进的,持久的防御。
此外,研究人员发现,在至少接受过一剂Moderna或Pfizer疫苗的那组人中,这些抗体进一步增强。这部分人产生的抗体对最令人担忧的SARS-CoV-2变种具有特别的抵抗力,例如首次在英国、南非和纽约市分离出来的变种。
这些强有力的抗体是由一群高度进化的记忆B细胞产生的,该团队发现,在疫苗的推动下,记忆B细胞会急剧膨胀。
这一发现表明,与目前的疫苗配合的适时增强剂可能会为从未患过该病的人提供额外的保护。
在Paul Bieniasz和Michel C. Nussenzweig的实验室进行的这项研究可供选择bioRxiv在同行评审期刊中发布之前。
进一步探索
更多信息:王子君等,接种疫苗自然增强对SARS-CoV-2的中和广度,bioRxiv(2021)。DOI: 10.1101 / 2021.05.07.443175
由...提供洛克菲勒大学
引文:疫苗对SARS-COV-2(2021年5月31日)收取自然免疫,从//www.pyrotek-europe.com/news/2021-05-vaccines-natural-immunity-sars-cov -.html
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