影响炎症性肠病基因的候选子HT-29转录组。选定的例子说明HT-29细胞的转录组的影响观察后不同的orf IBD候选基因的表达。击中被确定为基因探针从微阵列平台显示检测到表达HT-29(开或子表达式)的褶皱效果在回应一个给定的表达ORF大于两个基线相比,显示表达式在预期范围之外。为例,FUT2(左),终端酶代谢途径,没有影响转录组(0支安打);NOD2(中间),胞内受体PAMP时,只有边际影响转录组(28支安打)没有它的配体,HNF4A,已知的转录因子在肠道上皮细胞有一个中心的角色,有最强的效果(1123支)。每个点代表一个单一的从全基因组阵列检测探针标记HT-29特定基因的转录组。x轴显示log2-transformed值表达式(基线)在所有条件。y轴表示给定ORF的传导的影响,随着log2-transformed fold-induction与基线相比。天蓝色点探测器表达式值的预期范围内变化(Z | |≤2),橙色圆点代表探测范围之外的暗示地(Z | | > 2),和红点代表探测范围外(Z | | > 4)。灰色点探测器表达式值低于检测阈值。 B Impact of the expression of all IBD gene candidates on the transcriptome of HT-29 cells. ORFs are ordered along the x-axis by increasing total number of HITs (see Additional file 1: Table S5), with number of upregulated and downregulated HITs gene shown along the y-axis. Starred ORFs are previously reported IBD candidate causal genes and ORFs listed in red indicate known transcription factors (as defined by Lambert et al. [38]). Credit: DOI: 10.1186/s13073-021-00996-7