In-depth analysis of existing and robust databases guides new thinking around cancer and cardiovascular disease

Heart Attack
Myocardial Infarction or Heart Attack. Credit: Blausen Medical Communications/Wikipedia/CC-A 3.0

A new, robustly detailed retrospective cohort study on the incidence of cardiovascular disease (CVD) in more than 4,500,000 adult cancer patients published today inJACC: CardioOncology.

Clinical trials in oncology generally exclude patients with CVD, and randomized controlled trials on CVD generally do not include detailed cancer-related information. In this study, researchers make it apparent that the growing and unmet medical needs of cardio-oncology patients demand a new methodology to meet them.

"As the life expectancy ofincreases, so does the likelihood of developing other illnesses after that diagnosis," said Ian Paterson, MD, first author of the study and professor of medicine at the University of Alberta. "Our findings highlight the need for an even more collaborative approach tofor cancer patients and survivors."

The authors found that regardless of the cancer site, a new cancer diagnosis presents a significantly higher risk of cardiovascular mortality, heart failure, stroke or pulmonary embolism, especially in patients with genitourinary, thoracic, hematological and gastrointestinal cancers.

Thebetween CVD and the patient, cancer and treatment remains controversial. The primary elements of that relationship are that each patient presents specific and multifaceted risk factors for CVD; cancer itself is impacted by patients' physical and, often exacerbated by socioeconomic circumstances; and the course of each patient's cancer treatment.

Sharedamong CVD and cancer include smoking, obesity, diabetes and other comorbidities, and previous studies have shown that the incidence of developing these comorbidities increases afteras life expectancy increases.

The study compared newly diagnosed cancer patients and participants without cancer to help determine the risk of subsequent cardiovascular events. Those events include death, myocardial infarction, stroke,and pulmonary embolism in each group. The researchers created a time-to-event survival model adjusted for sociodemographic data and comorbidities.

The model is particularly robust in that it includes large administrative databases with validated risk and outcome indicators. Several health data repositories in Alberta, Canada, were utilized to create an extraordinarily large, population-based cohort of participants with extensive cancer and cardiovascular events.

"Our study has several novel aspects when compared to prior studies, which typically included one cancer site only," said Marcello Tonelli, MD, SM MSc, senior author of the study and professor of medicine at the University of Calgary. "Ours is uniquely comprehensive in that it includes data on site, stage and time from diagnosis, with evaluation of other relevant and interesting cardiovascular outcomes."


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更多的信息:D. Ian Paterson et al, Incident Cardiovascular Disease Among Adults With Cancer: A Population-Based Cohort Study,JACC: CardioOncology(2022).DOI: 10.1016/j.jaccao.2022.01.100
Citation: In-depth analysis of existing and robust databases guides new thinking around cancer and cardiovascular disease (2022, March 15) retrieved 1 August 2022 from //www.pyrotek-europe.com/news/2022-03-in-depth-analysis-robust-databases-cancer.html
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