−5) for which the minor allele was protective. The size of each point represents the total number of independent suggestive SNPs for each of the eight phenotypes. The horizontal dashed line represents the mean proportion of protective minor alleles across all eight phenotypes. Point colors match the protective enrichment color scale described in panel b. b, Protective (blue) or risk (red) enrichment at four two-sided CMH enrichment P-value thresholds for each of the eight phenotypes relative to the remaining seven phenotypes. Darker shades correspond to greater magnitude of enrichment (larger CMH OR). Asterisks represent significance of CMH enrichment test (unadjusted two-sided *P < 0.0016; **P < 1 × 10−10; ***P < 1 × 10−100). Credit: Nature Genetics (2022). DOI: 10.1038/s41588-022-01042-x">
−5) for which the minor allele was protective. The size of each point represents the total number of independent suggestive SNPs for each of the eight phenotypes. The horizontal dashed line represents the mean proportion of protective minor alleles across all eight phenotypes. Point colors match the protective enrichment color scale described in panel b. b, Protective (blue) or risk (red) enrichment at four two-sided CMH enrichment P-value thresholds for each of the eight phenotypes relative to the remaining seven phenotypes. Darker shades correspond to greater magnitude of enrichment (larger CMH OR). Asterisks represent significance of CMH enrichment test (unadjusted two-sided *P < 0.0016; **P < 1 × 10−10; ***P < 1 × 10−100). Credit: Nature Genetics (2022). DOI: 10.1038/s41588-022-01042-x" width="800" height="459">
三种“扩展”的表型富集了与保护作用方向相关的小等位基因。a, y轴表示暗示性相关先导snp的百分比(双侧逆方差加权跨谱系P < 1 × 10)−5)，而小等位基因是有保护作用的。每个点的大小代表了8种表型中每一种的独立提示snp的总数。水平虚线表示保护性小等位基因在所有八种表型中的平均比例。点颜色与面板b中描述的保护性富集颜色刻度相匹配。b，相对于其余7个表型，8个表型中的每一个在4个双面CMH富集p值阈值处的保护性(蓝色)或风险(红色)富集。更深的阴影对应更大的富集幅度(更大的CMH OR)。星号表示CMH富集试验的显著性(未经调整的双面*P < 0.0016;** p < 1 × 10−10；*** p < 1 × 10−100)．信贷:自然遗传学(2022)。DOI: 10.1038 / s41588 - 022 - 01042 - x
−5) for which the minor allele was protective. The size of each point represents the total number of independent suggestive SNPs for each of the eight phenotypes. The horizontal dashed line represents the mean proportion of protective minor alleles across all eight phenotypes. Point colors match the protective enrichment color scale described in panel b. b, Protective (blue) or risk (red) enrichment at four two-sided CMH enrichment P-value thresholds for each of the eight phenotypes relative to the remaining seven phenotypes. Darker shades correspond to greater magnitude of enrichment (larger CMH OR). Asterisks represent significance of CMH enrichment test (unadjusted two-sided *P < 0.0016; **P < 1 × 10−10; ***P < 1 × 10−100). Credit: Nature Genetics (2022). DOI: 10.1038/s41588-022-01042-x" width="800" height="459">
