组比较,相关分析和诊断血清beta-synuclein和等离子pTau181的性能。(一)血清beta-synuclein和(B)血浆pTau181水平整倍体健康对照组之间比较无神经系统疾病(HC, n = 23)和成人患有唐氏综合症(DS)诊断出患有阿尔茨海默病(症状、sDS、n = 14)或没有广告(无症状,广告,n = 47)。组与多元线性回归相比log2转换后的生物标志物水平和协变量与年龄和性别。盒子是中位数和四分位范围;胡须是最小值和最大值。* * * * p < 0.0001。(C)血清beta-synuclein散点图和(D)等离子体pTau181水平随着年龄的增长。线性(HC)和二阶多项式回归(DS)估计执行时间的生物标志物变化实线所示(95%可信区间[CI])。垂直的虚线表示两个回归的年龄线发散(CIs不再重叠点95%)。点和三角形是单独的值。 (E, F) Receiver operating characteristic curve analysis of (E) beta-synuclein and (F) pTau181 levels for discrimination of the different groups. Beta-synuclein: HC vs sDS, area under the curve (AUC) = 0.99, 95% CI = 0.98–1.00; aDS vs sDS, AUC = 0.94, 95% CI = 0.85–1.00; HC vs aDS, AUC = 0.90, 95% CI = 0.81–0.99. pTau181: HC vs sDS, AUC = 0.97, 95% CI = 0.92–1.00; aDS vs sDS, AUC = 0.95, 95% CI = 0.90–1.00; HC vs aDS, AUC = 0.55, 95% CI = 0.40–0.70. (G, H) Spearman partial correlation analysis of (G) beta-synuclein and (H) pTau181 levels with achieved number of points relative to the number that could maximally be reached on the Cambridge Cognitive Examination for Older Adults with Down Syndrome (CAMCOG-DS), including age as covariate. Beta-synuclein: aDS, r = 0.15; sDS, r = −0.75. pTau181: aDS, r = 0.04; sDS, r = −0.69. Dots are individual values, and lines are from linear regression. Credit:神经病学年鉴(2022)。DOI: 10.1002 / ana.26360
“我们的数据表明,血液中的beta-synuclein水平已经上升的早期阿尔茨海默氏病,这与神经连接的崩溃,所谓的突触,”帕特里克Ockl博士解释了PD研究小组组长DZNE乌尔姆网站和乌尔姆大学神经学部门的医院。“我们这里有一个潜在的生物标志物,有助于发现早期痴呆早期phase-presumably十多年前症状成为清单。”At present, Alzheimer's disease is diagnosed and treated far too late, the scientist notes: "By then, the brain is already massively damaged. We need to start earlier to increase the chances of being able to effectively combat the disease. Beta-synuclein could open up a possibility for this. However, further studies are still needed to confirm our findings."
