油性和石炭纪的识别和映射。在HFD上四个星期后，来自GM4951的油性突变位点绘制的G3小鼠的肝甘油三酸酯数据（n = 10只小鼠在wt中； n = 10小鼠； n = 14小鼠在ref; n = 25小鼠het; n = 5小鼠; n = 5小鼠; n = 5小鼠在var）。B曼哈顿图显示了使用类似的比例测试计算出的p值，该图是从继承加性模型中计算出的。在HFD上四个星期后，来自GM4951的Carboniforicer突变位点绘制的G3小鼠的C肝脏甘油三酸酯数据（wt中的N = 19只小鼠； n = 19只小鼠； n = 16小鼠在ref; n = 26小鼠het; n = 8小鼠; n = 8小鼠; n = 8小鼠在var）。D曼哈顿图显示了使用类似的比例测试从继承加性模型中计算出的P值。E，F肝脏甘油三酸酯的数据R5938（油性）和R6446（石炭纪）在Superpedree分析中合并在一起，并在A和C中绘制（n = 29小鼠wt; n = 30小鼠Ref; n = 30小鼠ref; n = 51小鼠; n = 51小鼠het; n = var中的13只小鼠;曼哈顿地块如（b）和（d）中。 P values were calculated using a likehood-ratio test from an additive model of inheritance. WT, C57BL/6 J mice age-matched with G3 mice; REF, G3 mice homozygous for the reference allele of the indicated gene; HET, G3 mice heterozygous for the reference allele and for the mutant allele; VAR, G3 mice homozygous for the mutant allele. Each data point represents one mouse; mean (μ) and SD (σ) are indicated (a, c, e). Data are from one experiment. Credit:自然通讯（2022）。doi：10.1038/s41467-022-31812-4
