研究人员发现了新的脑瘤亚型，可以确定治疗无法治愈的脑癌

pre- vs post- adjuvant anti-PD1 treatment in available tumor (N=24) samples. B. OS according to TME^High and non-TME^High (TME^Low + TME^Med) subtypes who received adjuvant anti-PD1 therapy in the Zhao cohort (N=15 patients). C. Relative boxplots indicating the proportion of TME^Low, TME^Med and TME^High patients before administration of anti-PD1 treatment (left) and after anti-PD1 treatment (right) in available tumor and blood samples. D. Partition around medoids (PAM) clustering of the PVSRIPO cohort¹⁹Desjardins A. Gromeier M. Herndon J.E. Beaubier N. Bolognesi D.P. Friedman A.H. et al.Recurrent Glioblastoma Treated with Recombinant Poliovirus.New England Journal of Medicine. July 12, 2018; 379: 150-161CrossrefPubMedScopus (0)Google Scholar with available RNA-seq data (N=12), based on the cellular TME composition described by GBM-MCP-counter scores reveal 3 subtypes; TME^low, TME ^med and TME ^high. E. OS according to TME^Low and TME^Med and TME^High subtypes who received PVSRIPO therapy in the PVSRIPO cohort¹⁹Desjardins A. Gromeier M. Herndon J.E. Beaubier N. Bolognesi D.P. Friedman A.H. et al.Recurrent Glioblastoma Treated with Recombinant Poliovirus.New England Journal of Medicine. July 12, 2018; 379: 150-161CrossrefPubMedScopus (0)Google Scholar. Statistical test: Wilcoxon signed rank test. Kaplan Meier analysis; P value of log-ranked test. *P<0.05 ** P<0.01. Credit: Annals of Oncology (2022). DOI: 10.1016/j.annonc.2022.11.008">