SARS-CoV-2助推器剂量增加被动转移RBD-specific抗体。的影响,实验设计探讨孕产妇SARS-CoV-2 RBD-specific被动传播的疫苗接种免疫球蛋白抗体通过评估抗体滴度在母亲的血浆,UCB等离子体,新生儿血浆,母乳。B, RBD-specific IgG抗体滴度在孕产妇等离子体相对于第一次疫苗接种后的天数(n = 370个样本)。C, RBD-specific IgG抗体滴度50.59±4.46天,55.74±4.14天后升压剂(n = 77)。D, RBD-specific IgG抗体滴度在母亲的血浆后升压剂相对于天(n = 112)。E,免疫球蛋白水平同形像84.07±12.34天,58.47±8.98天后升压剂(n = 15双)。F, RBD-specific后母乳中的免疫球蛋白水平第一和第二剂疫苗(n = 179)。G,母乳免疫球蛋白水平37.84±3.80天,55.32±5.30天后助推器(n = 45双)。H, RBD-specific孕产妇升压后母乳中的免疫球蛋白抗体疫苗接种(n = 123)。我水平RBD-specific前57.50±8.17天母乳中的免疫球蛋白g同形像(n = 28)和117.23±11.32天后升压剂(n = 44)。 J, RBD-specific IgG titers in maternal circulation and umbilical cord plasma at delivery (n=45 pairs). K, Correlation between UCB and maternal RBD-specific IgG titers at delivery (n=45). L, RBD-specific IgG titers in UCB relative to days since first maternal vaccine dose (n=48). M, Overall comparison between maternal RBD-specific IgG antibodies at delivery and newborn RBD-specific IgG titers, independent of trimester at initial vaccination (n=35 pairs). N, Correlation (n=35) between RBD-specific IgG titers in newborn and maternal plasma at delivery. O, RBD-specific IgG titers in newborn plasma relative to days post maternal vaccination. Bar graphs show median values with the standard error of the mean. Asterisk indicates P<.03; double asterisks indicate P<.002; triple asterisks indicate P<.0002; quadruple asterisks indicate P<.0001.ELISA, enzyme-linked immunosorbent assay; EPT, end-point titers; IgG, immunoglobulin G; OD, optical density; RBD, receptor-binding domain; UCB, umbilical cord blood. Credit:美国产科和妇科MFM杂志》上(2022)。DOI: 10.1016 / j.ajogmf.2022.100830
