睡眠期间沉默S1 VIP INs可防止SNI后持续疼痛。a,实验时间轴和条件位置偏好(CPP)测试示意图。病毒感染两周后,小鼠接受SNI治疗,并在睡眠或清醒阶段每天抑制靶细胞,持续5天。CPP测试在最后一次抑制期后2-3周进行。b,显示在CPP室中花费时间的代表性热图。c,单个小鼠在生理盐水和利多卡因配对室中花费的时间(n = 5,5,5,6只小鼠;生理盐水vs利多卡因,P = 0.87, 0.0004, 0.0001, 0.90;与图2d相关)。d,单个小鼠在生理盐水和利多卡因配对室中花费的时间(n = 6,6,6,5,5,4只小鼠;生理盐水vs利多卡因,P = 0.81, 0.0035, 0.0063, 0.18, 0.74, 0.058; related to Fig. 2f). e, Time spent in the saline- and lidocaine-paired chambers for individual mice (n = 5 mice per group, saline vs. lidocaine, P = 0.91, 0.0022, 0.019, 0.66; related to Fig. 5e). f, Time spent in the saline- and lidocaine-paired chambers for individual mice (n = 4, 5, 4, 5 mice; saline vs. lidocaine, P = 0.36, 0.012, 0.011, 0.12; related to Fig. 6e). g, Time spent in the saline- and lidocaine-paired chambers for individual mice (n = 6 mice per group; saline vs. lidocaine, P = 0.11, 0.0010, 0.97, 0.49; related to Fig. 7b). Inset, experimental timeline. Mean ± s.e.m. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; NS, not significant; by two-sided paired t-test. Credit:自然神经科学(2023)。DOI: 10.1038 / s41593 - 022 - 01250 - y