在小鼠ADN中的种群记录。a, 360°LED屏幕内的记录环境示意图。比例尺，20厘米。b, GCaMP6f在ADN中的表达。在这项研究中，总共有12只小鼠被注射和植入，只有3只(扩展数据图1a-c)提供了足够的同时记录的HD细胞用于继续实验。比例尺，2毫米。c，极坐标系中具有高定向调谐的ADN单元的调谐曲线示例。红线和数字分别表示平均合成向量和PFD。R，相关系数。d, ADN的视场(FOV)，显示每个细胞的PFD。 Scale bar, 0.125 mm. e, The distribution of ADN cells recorded across mice (n = 3) and sessions (n = 99). The red line indicates the median (minimum, maximum, median, 25th percentile and 75th percentile, respectively, are as follows: mouse 1 (all): 38, 188, 105, 70 and 131; mouse 1 (HD): 35, 154, 96, 66 and 128; mouse 2 (all): 102, 168, 138, 126.5 and 147; mouse 2 (HD): 97, 154, 129, 114.75 and 139.75; mouse 3 (all): 90, 255, 174, 137 and 204.5; mouse 3 (HD): 88, 239, 162.5, 133 and 195.5). The values above the box plots indicate the percentage of HD cells (green) among all recorded ADN cells (blue) shown as mean ± s.d. f, The distribution of correlation coefficients of ADN cells. The dashed yellow line represents the HD neuron detection threshold (shuffled control: P < 0.05). Data from three 10 min baseline recording sessions (one per mouse). g, HD population coverage of the azimuthal plane from one session. h, Projection of high-dimensional neural data onto a 2D polar plane using a feedforward neural network during a baseline recording. i, HD decoding. Top, log-likelihood distribution across time. Bottom, measured HD (blue) and decoded HD (red) using maximum likelihood. j, The distribution of the absolute residual error across baseline recordings from the first experiment (n = 42 sessions). Credit:自然(2023)。DOI: 10.1038 / s41586 - 023 - 05813 - 2
