实验设计。在训练阶段,我们应用170 faciliatory配对经颅磁刺激脉冲的表示正确的外展大拇指breves肌肉在左侧初级运动皮层在记录肌肉唤起势(议员)从目标肌肉。第(ⅱ型)经颅磁刺激脉冲是被动运动阈值(MT)调整到95%,第二个(超阈值的)脉冲130%被动太。诱导faciliatory效应,inter-stimulus两经颅磁刺激脉冲之间的时间间隔(ISI)被设置为12 ms。每个每个paired-pulse TMS应用程序的第一个阈下脉冲是搭配的两声刺激(830 Hz或1480 Hz,抵消在参与者)。Intertrial间隔6 s长。调节阶段长18分钟。20分钟后,调节阶段,测试阶段开始。在测试阶段,我们应用100年超阈值的单一经颅磁刺激脉冲130%太一样用于第二经颅磁刺激脉冲在训练阶段。50单经颅磁刺激脉冲是搭配条件语气(白色的铃铛)和50控制音调(黑钟)。他们的订单是伪随机选择。 The tone and the single TMS pulse were presented simultaneously as during the conditioning phase. Like in the conditioning phase, inter-trial intervals were set to 6 s. The statistical comparison of single-pulse TMS MEP amplitudes paired with the conditioned tone vs. control tone was used to assess successful conditioning. Credit:科学报告(2023)。DOI: 10.1038 / s41598 - 023 - 32894 - w
